GMP Cleaning Ongoing Best Practices

Good Manufacturing Practices (GMP) are the practices required to ensure the safety of manufactured products – whether it be in the pharmaceutical, food, or cosmetic industry. GMP are guidelines determined by WHO and are necessary to minimize the risk of contamination.

Maintaining the safety of these products requires ongoing cleaning best practices. These are routine cleaning practices usually done throughout the day. Below we take a look at a few examples.

General Ongoing Best Practices in GMP Facility

General GMP cleaning is about constant maintenance. In other words, employees should follow the “clean as you go” principle. This will help to keep work areas clean throughout the day. This is important as employees work with various products during the day. As a result, one big clean at the end of the day won’t prevent contamination. Some of these general cleaning best practices include:

  • Cleaning up spills as soon as they happen
  • Cleaning and sanitizing workstations between products
  • Keeping workstations organized and neat
  • Sweeping and vacuuming between products

These cleaning practices are essential to minimize cross-contamination.

Best Practices for Employees and Contractors

A clean space needs clean employees and contractors. Too often there is the contamination of manufactured products and workspaces by employees who have not followed the cleaning guidelines and codes.
There are two main areas when it comes to employee cleanliness. These are personal hygiene and organizational hygiene processes.

Personal hygiene

All employees should come to work in clean clothes and use clean lab coats if necessary. Employees should also have clean and tidy hair. Employees should pull back long hair and tuck away remaining strands under a hair net.

Organizational hygiene

This relates to the employee’s hygiene practices throughout the workday. For example, employees must ensure they practice regular hand washing and sanitizing before and after working with products. Organizational hygiene practices also require employees to wear:

  • hairnets
  • disposable gloves
  • lab coats
  • shoe covers

Employees and contractors should also avoid eating or drinking in the designated clean rooms and surroundings.

Ongoing Washroom GMP Procedures

Good washroom practices are essential to minimize contamination. Therefore, it’s no surprise that these practices form part of ongoing GMP cleaning procedures.

All washrooms should include adequate handwashing facilities. This includes hot and cold running water, liquid soap and sanitizer, as well as proper drying facilities.

Paper towels are best as they dry hands properly unlike hot-air dryers that often leave hands slightly damp.

Adhering to Washroom GMP cleaning procedures requires properly trained staff and personnel to carry out daily cleaning. The Quality Assurance Department (QAD) needs to monitor and oversee these members of staff.

The QAD is responsible for overseeing that staff clean washrooms effectively by using the correct products and detergents.

Some areas of the washroom that require daily cleaning include:

  • The washbasins
  • Service dispensers and receptacles
  • Urinals
  • Toilet bowls
  • Bathroom floors

Waste Disposal Ongoing Best Practices

Waste disposal is a key part of ongoing GMP cleaning best practices. According to guidelines and codes, you should dispose of waste daily. It is an important part of all manufacturing industries, but particularly the pharmaceutical industry.

There are two key processes in waste disposal. These are collection and disposal.


The collection process involves separating and storing waste in sanitized and labeled containers. This involves separating solid waste from chemical waste. Chemical waste is then further separated based on its hazardous components.

When collecting the waste employees must wear the correct PPE. This includes gloves, masks, lab coats, and shoe covers.

Then employees place the waste in its designated sanitized container. This should be kept away from all manufactured products.


Daily disposal of waste is necessary to adhere to the strict codes and ordinances of GMP. Solid waste is compacted and collected by a contracted disposal company.

Chemical and liquid waste should be delivered to a licensed and regulated disposal company. This is important to avoid chemical waste in our sewers.


To prevent contamination there must be adherence to various standards and practices.

So, be sure to follow these ongoing GMP cleaning procedures. That way, you can ensure optimum safety of all your manufactured products.

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